Thought need to be offered to the discontinuation of promethazine HCl and to using other medication if these reactions come about. Respiratory despair, nightmares, delirium, and agitated actions have also been documented in some of these people.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients a lot less than 6 many years of age, mainly because The mixture may result in fatal respiratory despair in this age population. It is crucial that promethazine with codeine syrup is calculated with an accurate measuring unit (see Safety measures-Facts For Clients).
Promethazine with codeine syrup is indicated for that momentary relief of coughs and upper respiratory indicators involved with allergy or perhaps the typical cold.
Test with your doctor right away In case you have indications of pale or blue lips, fingernails, or skin; tough or troubled respiratory; irregular, quickly, sluggish, or shallow breathing; or shortness of breath. These can be signs of a ailment referred to as respiratory despair .
The mix of promethazine hydrochloride and codeine phosphate ought to be employed with caution in pediatric sufferers six yrs and more mature (see Warnings-Use in Pediatric Patients).
Check out with your physician or healthcare facility crisis place instantly In case your baby demonstrates signs of amplified sleepiness (in excess of usual), problem breastfeeding, trouble respiratory, or limpness. These can be indications of an overdose and wish speedy healthcare interest. This medication could possibly be habit-forming. Should you think that the medicine just isn't Performing in addition, do not use greater than your prescribed dose. Get in touch with your medical professional for Recommendations. Utilizing narcotics for a long time might cause extreme constipation. To circumvent this, your medical doctor might immediate you to take laxatives, drink loads of fluids, or maximize the amount of fiber in the diet regime. You'll want to Stick to the directions meticulously, simply because continuing constipation can result in more really serious issues. This medicine may well cause a number of people to become dizzy, drowsy, or considerably less inform than they are Typically. Will not travel or do the rest that can be unsafe until you understand how this drugs influences you. You may additionally come to feel lightheaded when finding up abruptly from a lying or sitting position, so rise up slowly but surely. This medication will include to the consequences of Liquor and also other CNS depressants (medicines which make you drowsy or significantly less alert). Some samples of CNS depressants are antihistamines or drugs for hay fever, allergy symptoms, or colds, sedatives, click here tranquilizers, or sleeping medicine, prescription pain drugs or narcotics, medicine for seizures or barbiturates, or anesthetics, which includes some dental anesthetics. Verify with your healthcare medical professional or dentist right before getting any of the above Whilst you or your child are utilizing this drugs. Promethazine may perhaps increase your risk for convulsions (seizures). It might also trigger dystonia (motion dysfunction).
Anticholinergics – Concomitant use of other brokers with anticholinergic Attributes need to be undertaken with caution.
Carcinogenicity research were being done with codeine. Two-12 months research in F344/N rats and B6C3F1 mice ended up performed to evaluate the carcinogenic likely of codeine. No proof of tumorigenicity was noticed in male and woman rats at codeine dietary doses around 70 and eighty mg/kg/day (somewhere around comparable to fifteen and twenty occasions, the MRHD on a mg/m2 foundation, respectively).
Promethazine is contraindicated in comatose states, As well as in folks regarded to be hypersensitive or to own experienced an idiosyncratic reaction to promethazine or to other phenothiazines.
Even so, codeine should be administered only beneath shut supervision to patients with a background of drug abuse or dependence.
If a nursing mother is undoubtedly an extremely-fast metabolizer of codeine, it may lead to morphine overdose while in the nursing newborn and bring about pretty severe Uncomfortable side effects. For nursing moms getting this medication:
Drug interactions may well modify how your medications perform or raise your chance for critical side effects. This doc isn't going to contain all feasible drug interactions.
Be sure to know the way you react to this medicine before you generate, use devices, or do anything that can be perilous if You're not alert .
Prescription price ranges may differ from pharmacy to pharmacy and so are subject matter to alter. The pricing estimates provided are depending on the most recent information available and could transform based upon when you really fill your prescription in the pharmacy.